EF1A-NANOG_h lentivirus

NANOG is a transcription factor important for maintaining the self-renewal capacity of undifferentiated stem cells. Ectopic expression of NANOG has been used to generate iPS cells in culture.

Human elongation factor-1 alpha (EF-1 alpha) is a constitutive promoter of human origin that can be used to drive ectopic gene expression in various in vitro and in vivo contexts.EF-1 alpha (or EF1a) is often useful in conditions where other promoters (such as CMV) have diminished activity or have been silenced (as in embryonic stem cells).

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