ATXN3 Full-Length ORF: Human Gene Retrovirus

Gene ID: 4287

Synonym(s): AT3, ATX3, JOS, MJD, MJD1, SCA3

Description: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2016].

There is one cDNA ORF sequence of this gene in the NCBI database that is embedded in this clone; however, the amino acid sequences are not completely identical. The detailed alignment results are at the bottom of the Product Detail table below. For more detailed information regarding this clone and its ORF, please contact tech@cellomicstech.com.